You can use time to more fully resonate with your readers on a real and believable level while you begin to discard the gimmicks that threaten that bond. For example, from the git-go in Funky, I would break the fourth wall on a day-to-day basis by having a character do a side-glance to the reader (a device I unashamedly “borrowed” from Tom K. Ryan’s masterful strip Tumbleweeds . . . I’m done with it now and have since returned it). I stopped doing that because, while it’s funny, you lose the investment and involvement of the audience. They know the characters are going to be just fine, and they don’t really care about their fate. By breaking the fourth wall, I inject myself into the story to wink at the reader as we share the joke. Now, however, I began telling stories where my presence was less intrusive and less needed.
From the introduction to The Complete Funky Winkerbean Volume 10